Name |
Description of cell line |
Original reference |
Origin |
Sex & Age |
Source |
Myeloid |
HEL |
Erythroleukemia cell line (AML M6 in relapse after treatment for Hodgkin's disease) |
Martin et al., Science 216: 1233 (1982) |
Peripheral blood |
Male, 30 |
DSMZ |
HL-60 |
Acute promyelocytic leukemia (APL) cell line |
Collins et al., Nature 270: 347-349 (1977) |
Peripheral blood |
Female, 35 |
DSMZ |
HMC-1 |
Mastcell leukemia cell line |
Butterfield et al., Leukemia Res. 12: 345-355 (1988) |
Peripheral blood |
Male, 52 |
KN1 |
K-562 |
Chronic myeloid leukemia (CML) cell line |
Lozzio et al., J Natl Cancer Inst 50: 535 (1973) |
Pleural effusion |
Female, 53 |
DSMZ |
NB-4 |
Acute promyelocytic leukemia (APL) cell line |
Lanotte et al., Blood 77: 1080 (1991) |
Bone marrow |
Female, 23 |
DSMZ |
THP-1 |
Acute monocytic leukemia (AML) cell line |
Tsuchiya et al., Int J Cancer 26: 171 (1980) |
Peripheral blood |
Male, 1 |
DSMZ |
U-937 |
Myelomonocytic histiocytic lymphoma cell line |
Sundström C, Nilsson K., Int J Cancer 17:565-577 (1976) |
Pleural effusion |
Male, 37 |
KN1 |
Lymphoid |
Daudi |
Human Burkitt lymphoma cell line |
Klein et al., Cancer Res 28: 1300 (1968) |
Orbital biopsy |
Male, 16 |
DSMZ |
HDLM-2 |
Hodgkin lymphoma cell line |
Drexler et al., Leuk Res 10: 487 (1986) |
Pleural effusion |
Male, 74 |
DSMZ |
Karpas-707 |
Multiple myeloma cell line |
Karpas et al., Lancet Apr 24;1(8278): 931-3 (1982) |
Bone marrow and peripheral blood |
Male, 53 |
KN1 |
LP-1 |
Multiple myeloma cell line |
Pegoraro et al., Blood 73: 1020 (1989) |
Peripheral blood |
Female, 56 |
DSMZ |
MOLT-4 |
Acute lymphoblastic leukemia (T-ALL) cell line |
Minowada et al., J Natl Cancer Inst 49: 891 (1972) |
Peripheral blood |
Male, 19 |
DSMZ |
REH* |
Pre-B cell leukemia cell line (ALL, first relapse) |
Rosenfeld et al., Nature 267: 841–3 (1977) |
Peripheral blood |
Female, 15 |
DSMZ |
RPMI-8226 |
Multiple myeloma cell line |
Matsuoka et al., Proc Soc Exp Biol Med 125: 1246 (1967) |
Peripheral blood |
Male, 61 |
DSMZ |
U-266/70 |
Multiple myeloma cell line (1970, IL-6-dependent) |
Nilsson et al Clin Exp Immunol 7:477-489 (1970) |
Peripheral blood |
Male, 53 |
KN1 |
U-266/84 |
Multiple myeloma cell line (1984, in vitro differentiated) |
Hellman et al., Eur J Immunol 18:905-910 (1988) |
Peripheral blood |
Male, 53 |
KN1 |
U-698 |
B-cell lymphoma cell line (lymphoblastic lymphosarcoma) |
Nilsson et al., Int J Cancer 13: 808-823 (1974) |
Tonsil |
Male, 7 |
DSMZ |
Brain |
SH-SY5Y |
Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH |
Biedler et al., Cancer Res 33: 2643 (1973) |
Bone marrow |
Female, 4 |
DSMZ |
U-138 MG |
Glioblastoma cell line |
Ponten et al., Acta Pathol Microbiol Scand 74: 465 (1968) |
Brain |
Male, 47 |
DSMZ |
U-251 MG |
Glioblastoma cell line |
Westermark B., Int J Cancer12: 438 (1973) |
Brain |
Male |
BW2 |
U-87 MG** |
Glioblastoma, astrocytoma cell line |
Ponten J., Macintyre EH., Acta Pathol. Microbiol. Scand. 74: 465-486 (1968) |
Brain |
Male, 44 |
LGC/ATCC |
Lung |
A549 |
Lung carcinoma cell line |
Giard et al., J Natl Cancer Inst 51: 1417 (1973) |
Lung |
Male, 58 |
DSMZ |
SCLC-21H |
Small cell lung carcinoma cell line |
Bepler et al., J Cancer Res Clin Oncol 113: 31 (1987) |
Pleural effusion |
Male, 46 |
DSMZ |
Abdominal |
CACO-2 |
Colon adenocarcinoma cell line |
Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977) |
Colon |
Male, 72 |
DSMZ |
CAPAN-2 |
Pancreas adenocarcinoma cell line |
Kyriazis et al., Cancer Res 46: 5810 (1986) |
Pancreas |
Male, 56 |
DSMZ |
Hep G2 |
Hepatocellular carcinoma cell line |
Aden et al., Nature 282: 615 (1979) |
Liver |
Male, 15 |
DSMZ |
Breast, female reproductive system |
AN3-CA |
Metastatic endometrial adenocarcinoma cell line |
Dawe et al., J Natl Cancer Inst 33: 441 (1964) |
Lymph node |
Female, 55 |
DSMZ |
EFO-21 |
Metastatic ovarian serous cystadenocarcinoma cell line |
Simon et al., J Natl Cancer Inst 70: 839 (1983) |
Ascites |
Female, 56 |
DSMZ |
HeLa |
Cervical epithelial adenocarcinoma cell line |
Scherer et al., J Exp Med 97: 695 (1953) |
Cervix |
Female, 31 |
DSMZ |
MCF7 |
Metastatic breast adenocarcinoma cell line |
Soule et al., J Natl Cancer Inst 51: 1409 (1973) |
Pleural effusion |
Female, 69 |
DSMZ |
SiHa |
Cervical squamous cell carcinoma cell line, integrated 1-2 copies of HPV16 |
Friedl F. et al.Proc., Soc. Exp. Biol. Med. 135: 543-545 (1970) |
Cervix |
Female, 55 |
LGC/ATCC |
SK-BR-3 |
Metastatic breast adenocarcinoma cell line |
Fogh J, editor. Human tumor cells in vitro. New York: Plenum Press (1975) |
Pleural effusion |
Female, 43 |
LGC/ATCC |
Urinary, male reproductive system |
NTERA-2 |
Metastatic embryonal carcinoma cell line, cloned from TERA-2 |
Fogh & Trempe, Human Tumor Cells in Vitro : 115 (1975) |
|
Male, 22 |
DSMZ |
PC-3 |
Metastatic poorly differentiated prostate adenocarcinoma cell line |
Kaighn et al., Invest Urol 17: 16-23 (1979) |
Bone marrow |
Male, 62 |
DSMZ |
RT4 |
Urinary bladder transitional cell carcinoma cell line |
Rigby et al., Br J Cancer 24: 746 (1970) |
Urinary bladder |
Male, 63 |
DSMZ/ECACC |
Skin |
A-431 |
Epidermoid carcinoma cell line |
Giard et al., J Natl Cancer Inst 51: 1417 (1973) |
Skin |
Female, 85 |
DSMZ |
HaCaT |
Keratinocyte cell line |
Boukamp et al., J Cell Biol Mar 106(3): 761 (1988) |
Skin |
Male |
NEF3 |
SK-MEL-30 |
Metastatic malignant melanoma cell line |
Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976) |
Subcutis |
Male, 67 |
DSMZ |
WM-115 |
Malignant melanoma cell line |
Westermark B. et al, Proc Natl Acad Sci U S A. Oct; 83(19): 7197 (1986) |
Skin |
Female, 58 |
BW2 |
Sarcoma |
RH-30 |
Metastatic rhabdomyosarcoma cell line |
Douglass et al., Cytogenet Cell Genet 45: 148-155 (1987) |
Bone marrow |
Male, 17 |
DSMZ |
U-2 OS |
Osteosarcoma cell line |
Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967) |
Bone |
Female, 15 |
LGC/ATCC |
U-2197 |
Malignant fibrous histiocytoma cell line |
Genberg et al., Am J Pathol 135: 1185 (1989) |
Subcutis |
Male, 79 |
DSMZ |
Miscellaneous |
BEWO |
Metastatic choriocarcinoma cell line |
Pattillo et al., Cancer Res 28: 1231-1236 (1968) |
Brain |
Male |
DSMZ |
HEK 293 |
Embryonal kidney cell line, transformed by adenovirus type 5 |
Graham et al., J Gen Virol 36: 59 (1977) |
Embryonal kidney |
Female |
DSMZ |
HTh 83 |
Anaplastic thyroid carcinoma cell line |
Dahlman et al., J. Pathol. 191: 376-386, 2000 |
Thyroid |
Male, 67 |
NEH4 |
TIME |
Telomerase-immortalized human microvascular endothelial cells (pooled) |
Venetsanakos et el., Exp Cell Res., Feb 1;273(1): 21-33 (2002) |
Skin |
Male |
LCW5 |
Mouse |
NIH 3T3 |
Mouse embryonal fibroblast cell line |
Aaronson et al., J Cell Physio 72(2): 141-148 (1968) |
Embryo |
|
DSMZ |