PROTEIN CLASSES

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Function and compartment based

Protein class

No of genes

No of genes with antibodies

Source

Enzymes » 3226 2990
CD markers 378 316 UniProt
Blood group antigen proteins 31 26 UniProt
Nuclear receptors 48 38 NucleaRDB
Transporters » 986 846 TCDB
Ribosomal proteins 153 140 UniProt
G-protein coupled receptors » 774 391 UniProt
Voltage-gated ion channels » 132 104 IUPHAR-DB
Predicted membrane proteins » 5570 4478 MDM
Predicted secreted proteins » 3171 2662 MDSEC prediction
Plasma proteins 3761 3494 Plasma Proteome Database
Transcription factors » 1510 1248 UMG
Mitochondrial proteins 781 729 MitoProteome
RNA polymerase related proteins 33 30 KEGG
RAS pathway related proteins 227 200 KEGG
Citric acid cycle related proteins 30 29 KEGG
Cytoskeleton related proteins 369 345 GO


Disease and drug related

Protein class

No of genes

No of genes with antibodies

Source

Cancer-related genes » 1703 1530
Candidate cardiovascular disease genes 162 147 Plasma Proteome Institute
Disease related genes 3254 2875 UniProt
FDA approved drug targets » 620 527 Drugbank
Potential drug targets 1020 911 HPA


Evidence based

Protein class

No of genes

No of genes with antibodies

Source

Mapped to UniProt SWISS-PROT » 19076 16548 UniProt
Protein evidence (Kim et al 2014) 12923 11920 Kim et al 2014
Protein evidence (Ezkurdia et al 2014) 11743 10912 Ezkurdia et al 2014