CDC27

GENE INFORMATION

? »

Gene name

CDC27 (HGNC Symbol)

Synonyms

ANAPC3, APC3, D0S1430E, D17S978E, NUC2

Description

Cell division cycle 27 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

45195069 - 45266788

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000004897 (version 75.37)

Entrez gene

996

UniProt

P30260 (UniProt - Evidence at protein level)

neXtProt

NX_P30260

Antibodypedia

CDC27 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
CDC27-001
 
CDC27-002
 
CDC27-004
 
CDC27-005
 
CDC27-006
 
CDC27-011
 
CDC27-012
 
CDC27-013
 
CDC27-014
 
CDC27-015
 
CDC27-016
 
CDC27-017
 
CDC27-018
 
CDC27-019
 
CDC27-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDC27-001 ENSP00000066544
ENST00000066544
P30260
Show all »
Show » Show » 824 91.9 No 0
CDC27-002 ENSP00000434614
ENST00000531206
P30260
Show all »
Show » Show » 830 92.6 No 0
CDC27-004 ENSP00000432211
ENST00000533415
E9PRZ6
Show all »
Show » 94 10.8 No 1
CDC27-005 ENSP00000437339
ENST00000527547
G5EA36
Show all »
Show » Show » 823 91.7 No 0
CDC27-006 ENSP00000432105
ENST00000526866
F6QPS0
Show all »
Show » 343 37.8 No 0
CDC27-011 ENSP00000466424
ENST00000532893
K7EMA6
Show all »
Show » 52 6 No 0
CDC27-012 ENSP00000460454
ENST00000575483
I3L3H6
Show all »
Show » 233 25.9 No 0
CDC27-013 ENSP00000460424
ENST00000573550
Show » 75 8.6 No 1
CDC27-014 ENSP00000460279
ENST00000571643
Show » Show » 163 18.8 No 0
CDC27-015 ENSP00000460132
ENST00000573502
Show » 113 12.3 No 0
CDC27-016 ENSP00000460830
ENST00000570740
Show » 33 3.6 No 0
CDC27-017 ENSP00000460061
ENST00000570818
I3L2Z8
Show all »
Show » 86 9.6 No 0
CDC27-018 ENSP00000458904
ENST00000574304
Show » Show » 59 6.5 No 0
CDC27-019 ENSP00000459307
ENST00000576484
Show » 103 10.9 No 0
CDC27-201 ENSP00000392802
ENST00000446365
B4DL80
Show all »
Show » Show » 763 84.9 No 0