PRKAR2B

GENE INFORMATION

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Gene name

PRKAR2B (HGNC Symbol)

Synonyms

PRKAR2

Description

Protein kinase, cAMP-dependent, regulatory, type II, beta (HGNC Symbol)

Entrez gene summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q22.3

Chromosome location (bp)

106685094 - 106802256

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005249 (version 75.37)

Entrez gene

5577

UniProt

P31323 (UniProt - Evidence at protein level)

neXtProt

NX_P31323

Antibodypedia

PRKAR2B antibodies
 

PROTEIN VIEW

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PRKAR2B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKAR2B-001 ENSP00000265717
ENST00000265717
P31323
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