ITGAL

GENE INFORMATION

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Gene name

ITGAL (HGNC Symbol)

Synonyms

CD11A, LFA-1

Description

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (HGNC Symbol)

Entrez gene summary

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

30483979 - 30534506

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005844 (version 75.37)

Entrez gene

3683

UniProt

P20701 (UniProt - Evidence at protein level)

neXtProt

NX_P20701

Antibodypedia

ITGAL antibodies
 

PROTEIN VIEW

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 « 
 
ITGAL-001
 
ITGAL-002
 
ITGAL-003
 
ITGAL-004
 
ITGAL-007
 
ITGAL-008
 
ITGAL-009
 
ITGAL-010
 
ITGAL-011
 
ITGAL-020
 
ITGAL-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAL-001 ENSP00000349252
ENST00000356798
P20701
Show all »
Show » Show » 1170 128.8 Yes 1
ITGAL-002 ENSP00000350886
ENST00000358164
P20701
Show all »
Show » Show » 1086 119.2 Yes 1
ITGAL-003 ENSP00000454342
ENST00000562857
B4DQ77
Show all »
Show » Show » 162 17.4 Yes 0
ITGAL-004 ENSP00000409377
ENST00000433423
B4E021
Show all »
Show » Show » 404 44.8 Yes 1
ITGAL-007 ENSP00000456888
ENST00000564118
H3BSV1
Show all »
Show » Show » 204 22 Yes 0
ITGAL-008 ENSP00000461006
ENST00000569725
I3L468
Show all »
Show » Show » 41 4.5 No 0
ITGAL-009 ENSP00000457785
ENST00000568926
H3BUT3
Show all »
Show » 109 12.2 Yes 0
ITGAL-010 ENSP00000456521
ENST00000562652
H3BS37
Show all »
Show » 90 9.7 Yes 0
ITGAL-011 ENSP00000454908
ENST00000565864
H3BNL5
Show all »
Show » Show » 55 6 Yes 0
ITGAL-020 ENSP00000458739
ENST00000563615
Show » 38 4.2 No 0
ITGAL-201 ENSP00000408615
ENST00000454514
B4DQ77
Show all »
Show » Show » 162 17.4 Yes 0