Expression of USH1C in cancer - Staining overview

The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.

The cancers can be ordered histologically or alphabetically.

For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.

At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the literature conformity for the staining pattern revealed by that specific antibody.

Antibody HPA027398

Antibody HPA027492

Antibody HPA028033

Antibody CAB013690

Tissue

Antibody staining

Summary

Colorectal, pancreatic and renal cancers as well as a majority of breast, prostate, endometrial, gastric showed moderate cytoplasmic positivity. Most of the remaining malignancies were in general weakly stained or negative. Among tumors, additional membranous staining was seen in colorectal, pancreatic and renal cancers. Many cases of gliomas, lymphomas and testicular cancers were negative.

Colorectal cancers displayed weak to moderate cytoplasmic staining. In addition a few cases of stomach, pancreatic, liver, lung and ovarian cancer showed moderate cytoplasmic staining. Remaining malignancies were weakly stained or negative.

Most malignancies showed moderate to strong cytoplasmic and/or membranous positivity. Malignant lymphomas, gliomas and melanomas were generally negative.

Colorectal cancers as well as several liver, prostate, endometrial, pancreatic and gastric cancers showed moderate cytoplasmic staining combined with cases of membranous staining. Remaining malignancies were weakly stained or negative.

Literature conformity

Consistent with extensive gene/protein characterization data

Consistent with gene/protein characterization data

Consistent with extensive gene/protein characterization data

Level of antibody staining/expression

High
Medium
Low
Not detected

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.