TFAP2B

GENE INFORMATION

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Gene name

TFAP2B (HGNC Symbol)

Synonyms

AP2-B

Description

Transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

50786436 - 50815326

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008196 (version 75.37)

Entrez gene

7021

UniProt

Q92481 (UniProt - Evidence at protein level)

neXtProt

NX_Q92481

Antibodypedia

TFAP2B antibodies
 

PROTEIN VIEW

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TFAP2B-001
 
TFAP2B-002
 
TFAP2B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFAP2B-001 ENSP00000377265
ENST00000393655
Q92481
Show all »
Show » Show » 460 50.5 No 0
TFAP2B-002 ENSP00000342252
ENST00000344788
198 22.1 No 0
TFAP2B-201 ENSP00000263046
ENST00000263046
Q92481
Show all »
Show » Show » 469 51.5 No 0