MMP25

GENE INFORMATION

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Gene name

MMP25 (HGNC Symbol)

Synonyms

MMP20, MMPL1, MT6-MMP

Description

Matrix metallopeptidase 25 (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

3096682 - 3110727

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008516 (version 75.37)

Entrez gene

64386

UniProt

Q9NPA2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPA2

Antibodypedia

MMP25 antibodies
 

PROTEIN VIEW

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MMP25-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP25-001 ENSP00000337816
ENST00000336577
Q9NPA2
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