FMO1

GENE INFORMATION

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Gene name

FMO1

Synonyms

Description

Flavin containing monooxygenase 1 (HGNC Symbol)

Entrez gene summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

1

Cytoband

q24.3

Chromosome location (bp)

171217638 - 171255117

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010932 (version 75.37)

Entrez gene

2326

UniProt

Q01740 (UniProt - Evidence at transcript level)

neXtProt

NX_Q01740

Antibodypedia

FMO1 antibodies
 

PROTEIN VIEW

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FMO1-001
 
FMO1-003
 
FMO1-006
 
FMO1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FMO1-001 ENSP00000356724
ENST00000367750
Q01740
Show all »
Show » Show » 532 60.3 Yes 1
FMO1-003 ENSP00000346901
ENST00000354841
Q01740
Show all »
Show » Show » 532 60.3 Yes 1
FMO1-006 ENSP00000406982
ENST00000433267
Q5QPT3
Show all »
Show » Show » 208 23.3 Yes 0
FMO1-201 ENSP00000385543
ENST00000402921
B7Z3P4
Show all »
Show » Show » 469 52.8 Yes 1