LTF

GENE INFORMATION

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Gene name

LTF (HGNC Symbol)

Synonyms

HLF2

Description

Lactotransferrin (HGNC Symbol)

Entrez gene summary

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

46477136 - 46526724

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000012223 (version 75.37)

Entrez gene

4057

UniProt

P02788 (UniProt - Evidence at protein level)

neXtProt

NX_P02788

Antibodypedia

LTF antibodies
 

PROTEIN VIEW

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LTF-001
 
LTF-002
 
LTF-003
 
LTF-005
 
LTF-006
 
LTF-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LTF-001 ENSP00000231751
ENST00000231751
P02788
Show all »
Show » Show » 710 78.2 Yes 0
LTF-002 ENSP00000397427
ENST00000443496
E7EQB2
Show all »
Show » Show » 696 76.6 No 0
LTF-003 ENSP00000405546
ENST00000417439
E7ER44
Show all »
Show » Show » 708 78 Yes 0
LTF-005 ENSP00000395234
ENST00000431944
C9JCF5
Show all »
Show » Show » 182 20.3 Yes 0
LTF-006 ENSP00000400254
ENST00000415180
C9J0S5
Show all »
Show » Show » 122 13.4 No 0
LTF-201 ENSP00000405719
ENST00000426532
P02788
Show all »
Show » Show » 666 73.2 No 0