WWTR1 - Gene info - The Human Protein Atlas

Gene name

WWTR1 (HGNC Symbol)

Synonyms

DKFZp586I1419, TAZ

Description

WW domain containing transcription regulator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

q25.1

Chromosome location (bp)

149235022 - 149454501

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000018408 (version 75.37)

Entrez gene

25937

UniProt

Q9GZV5 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WWTR1-001

ENSP00000419465
ENST00000465804

Q9GZV5
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Q9GZV5 [Direct mapping]
WW domain-containing transcription regulator protein 1
C9J038 [Target identity:47%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9JR84 [Target identity:34%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9JQS8 [Target identity:27%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9J588 [Target identity:5%; Query identity:100%]
WW domain-containing transcription regulator protein 1

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017145 [stem cell division]
GO:0032835 [glomerulus development]
GO:0035329 [hippo signaling]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060271 [cilium morphogenesis]
GO:0060390 [regulation of SMAD protein import into nucleus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]

400

44.1

WWTR1-003

ENSP00000419234
ENST00000467467

Q9GZV5
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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

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400

44.1

WWTR1-004

ENSP00000353847
ENST00000360632

Q9GZV5
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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

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400

44.1

WWTR1-006

ENSP00000420159
ENST00000475579

C9JQS8
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C9JQS8 [Target identity:100%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9J588 [Target identity:19%; Query identity:100%]
WW domain-containing transcription regulator protein 1

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0032835 [glomerulus development]
GO:0042803 [protein homodimerization activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060271 [cilium morphogenesis]

109

11.3

WWTR1-007

ENSP00000417984
ENST00000460517

C9J588
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C9J588 [Target identity:100%; Query identity:100%]
WW domain-containing transcription regulator protein 1

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

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2.1

WWTR1-008

ENSP00000420120
ENST00000485352

C9JR84
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C9JR84 [Target identity:100%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9JQS8 [Target identity:78%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9J588 [Target identity:15%; Query identity:100%]
WW domain-containing transcription regulator protein 1

Show » « Hide

   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

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138

14.6

WWTR1-009

ENSP00000418580
ENST00000479238

C9J038
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C9J038 [Target identity:100%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9JR84 [Target identity:73%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9JQS8 [Target identity:57%; Query identity:100%]
WW domain-containing transcription regulator protein 1
C9J588 [Target identity:11%; Query identity:100%]
WW domain-containing transcription regulator protein 1

Show » « Hide

   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0032835 [glomerulus development]
GO:0042803 [protein homodimerization activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060271 [cilium morphogenesis]

189

20.5

WWTR1-010

ENSP00000417339
ENST00000472417

C9J337
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C9J337 [Target identity:100%; Query identity:100%]
WW domain-containing transcription regulator protein 1

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

247

27.7

WWTR1-012

ENSP00000418621
ENST00000471586

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

4.8

WWTR1-013

ENSP00000417862
ENST00000494754

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   COSMIC Somatic Mutations
   COSMIC Translocations
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Ezkurdia et al 2014)

2.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.