NRXN3

GENE INFORMATION

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Gene name

NRXN3 (HGNC Symbol)

Synonyms

C14orf60, KIAA0743

Description

Neurexin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

Chromosome

14

Cytoband

q24.3

Chromosome location (bp)

78708734 - 80330762

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000021645 (version 75.37)

Entrez gene

9369

UniProt

Q9HDB5 (UniProt - Evidence at protein level), Q9Y4C0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HDB5, NX_Q9Y4C0

Antibodypedia

NRXN3 antibodies
 

PROTEIN VIEW

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NRXN3-001
 
NRXN3-002
 
NRXN3-004
 
NRXN3-005
 
NRXN3-006
 
NRXN3-007
 
NRXN3-009
 
NRXN3-010
 
NRXN3-011
 
NRXN3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NRXN3-001 ENSP00000451648
ENST00000554719
Q9Y4C0
Show all »
Show » Show » 1061 117.3 No 1
NRXN3-002 ENSP00000450683
ENST00000554738
Q9Y4C0
Show all »
Show » Show » 1392 153.9 Yes 1
NRXN3-004 ENSP00000451672
ENST00000557594
Q9HDB5
Show all »
Show » Show » 637 69.3 Yes 1
NRXN3-005 ENSP00000281127
ENST00000281127
Q9HDB5
Show all »
Show » Show » 432 47.3 Yes 1
NRXN3-006 ENSP00000394426
ENST00000428277
Q9HDB5
Show all »
Show » Show » 459 50.7 Yes 1
NRXN3-007 ENSP00000451393
ENST00000555387
Q9HDB5
Show all »
Show » Show » 398 44 Yes 1
NRXN3-009 ENSP00000451947
ENST00000553631
G3V4R9
Show all »
Show » Show » 75 8.7 No 0
NRXN3-010 ENSP00000451754
ENST00000553363
Show » 175 18.9 No 0
NRXN3-011 ENSP00000450462
ENST00000557081
G3V247
Show all »
Show » Show » 120 13.8 No 0
NRXN3-201 ENSP00000338349
ENST00000335750
Q9Y4C0
Show all »
Show » Show » 1061 117.3 No 1