C8B

GENE INFORMATION

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Gene name

C8B

Synonyms

Description

Complement component 8, beta polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

1

Cytoband

p32.2

Chromosome location (bp)

57394883 - 57431813

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000021852 (version 75.37)

Entrez gene

732

UniProt

P07358 (UniProt - Evidence at protein level)

neXtProt

NX_P07358

Antibodypedia

C8B antibodies
 

PROTEIN VIEW

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C8B-001
 
C8B-201
 
C8B-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C8B-001 ENSP00000360281
ENST00000371237
P07358
Show all »
Show » Show » 591 66.9 Yes 0
C8B-201 ENSP00000440113
ENST00000535057
F5GY80
Show all »
Show » Show » 529 60 Yes 0
C8B-202 ENSP00000442548
ENST00000543257
F5H7G1
Show all »
Show » Show » 539 61.2 No 0