APBA2

GENE INFORMATION

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Gene name

APBA2 (HGNC Symbol)

Synonyms

D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11L

Description

Amyloid beta (A4) precursor protein-binding, family A, member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q13.1

Chromosome location (bp)

29129629 - 29410518

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000034053 (version 75.37)

Entrez gene

321

UniProt

Q99767 (UniProt - Evidence at protein level)

neXtProt

NX_Q99767

Antibodypedia

APBA2 antibodies
 

PROTEIN VIEW

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APBA2-001
 
APBA2-002
 
APBA2-004
 
APBA2-007
 
APBA2-008
 
APBA2-009
 
APBA2-010
 
APBA2-011
 
APBA2-201
 
APBA2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APBA2-001 ENSP00000453293
ENST00000558402
Q99767
Show all »
Show » Show » 749 82.5 No 0
APBA2-002 ENSP00000452722
ENST00000558330
Q99767
Show all »
Show » Show » 737 81.1 No 0
APBA2-004 ENSP00000453144
ENST00000561069
Q99767
Show all »
Show » Show » 749 82.5 No 0
APBA2-007 ENSP00000452699
ENST00000559709
Show » 4 0.5 No 0
APBA2-008 ENSP00000454001
ENST00000558804
H0YNG7
Show all »
Show » Show » 70 7.7 No 0
APBA2-009 ENSP00000453034
ENST00000560283
H0YL28
Show all »
Show » Show » 112 12.6 No 0
APBA2-010 ENSP00000453981
ENST00000558206
H0YNE8
Show all »
Show » Show » 27 3 No 0
APBA2-011 ENSP00000453715
ENST00000558358
H0YMS0
Show all »
Show » Show » 264 29.2 No 0
APBA2-201 ENSP00000409312
ENST00000411764
Q99767
Show all »
Show » Show » 737 81.1 No 0
APBA2-202 ENSP00000454171
ENST00000558259
Q99767
Show all »
Show » Show » 749 82.5 No 0