ZIC2

GENE INFORMATION

? »

Gene name

ZIC2 (HGNC Symbol)

Synonyms

HPE5

Description

Zic family member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q32.3

Chromosome location (bp)

100634026 - 100639018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000043355 (version 75.37)

Entrez gene

7546

UniProt

O95409 (UniProt - Evidence at protein level)

neXtProt

NX_O95409

Antibodypedia

ZIC2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ZIC2-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ZIC2-001 ENSP00000365514
ENST00000376335
O95409
Show all »
Show » Show » 532 55 No 0