SPA17

GENE INFORMATION

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Gene name

SPA17 (HGNC Symbol)

Synonyms

CT22, SP17

Description

Sperm autoantigenic protein 17 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

Chromosome

11

Cytoband

q24.2

Chromosome location (bp)

124543694 - 124567414

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064199 (version 75.37)

Entrez gene

53340

UniProt

Q15506 (UniProt - Evidence at protein level)

neXtProt

NX_Q15506

Antibodypedia

SPA17 antibodies
 

PROTEIN VIEW

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SPA17-001
 
SPA17-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPA17-001 ENSP00000432305
ENST00000532692
Q15506
Show all »
Show » Show » 151 17.4 No 0
SPA17-004 ENSP00000227135
ENST00000227135
Q15506
Show all »
Show » Show » 151 17.4 No 0