CDON - Gene info - The Human Protein Atlas

Gene name

CDON (HGNC Symbol)

Synonyms

CDO, CDON1, ORCAM

Description

Cell adhesion associated, oncogene regulated (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

Chromosome

Cytoband

q24.2

Chromosome location (bp)

125825691 - 125933230

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064309 (version 75.37)

Entrez gene

50937

UniProt

Q4KMG0 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDON-001

ENSP00000376458
ENST00000392693

Q4KMG0
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Q4KMG0 [Direct mapping]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PRD8 [Target identity:12%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PPQ7 [Target identity:11%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PNF2 [Target identity:8%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001708 [cell fate specification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002088 [lens development in camera-type eye]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007224 [smoothened signaling pathway]
GO:0007520 [myoblast fusion]
GO:0009952 [anterior/posterior pattern specification]
GO:0010172 [embryonic body morphogenesis]
GO:0014816 [satellite cell differentiation]
GO:0016021 [integral to membrane]
GO:0021987 [cerebral cortex development]
GO:0031012 [extracellular matrix]
GO:0042692 [muscle cell differentiation]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0045664 [regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048598 [embryonic morphogenesis]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051146 [striated muscle cell differentiation]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:2000179 [positive regulation of neural precursor cell proliferation]

1287

139.1

Yes

CDON-002

ENSP00000263577
ENST00000263577

Q4KMG0
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Q4KMG0 [Direct mapping]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PN78 [Target identity:50%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PRD8 [Target identity:13%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PPQ7 [Target identity:11%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PNF2 [Target identity:8%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

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GO:0001708 [cell fate specification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002088 [lens development in camera-type eye]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007224 [smoothened signaling pathway]
GO:0007520 [myoblast fusion]
GO:0009952 [anterior/posterior pattern specification]
GO:0010172 [embryonic body morphogenesis]
GO:0014816 [satellite cell differentiation]
GO:0016021 [integral to membrane]
GO:0021987 [cerebral cortex development]
GO:0031012 [extracellular matrix]
GO:0042692 [muscle cell differentiation]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:2000179 [positive regulation of neural precursor cell proliferation]

1264

136.5

Yes

CDON-004

ENSP00000436755
ENST00000534661

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

650

69.6

CDON-005

ENSP00000434212
ENST00000531586

E9PRD8
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E9PRD8 [Target identity:100%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PPQ7 [Target identity:86%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PNF2 [Target identity:67%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001708 [cell fate specification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002088 [lens development in camera-type eye]
GO:0005515 [protein binding]
GO:0007224 [smoothened signaling pathway]
GO:0007520 [myoblast fusion]
GO:0009952 [anterior/posterior pattern specification]
GO:0010172 [embryonic body morphogenesis]
GO:0014816 [satellite cell differentiation]
GO:0021987 [cerebral cortex development]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:2000179 [positive regulation of neural precursor cell proliferation]

165

17.6

Yes

CDON-006

ENSP00000432571
ENST00000531830

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

243

26.1

CDON-007

ENSP00000432901
ENST00000531738

E9PN78
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E9PN78 [Target identity:100%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

Show » « Hide

   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]

641

69.8

CDON-008

ENSP00000437176
ENST00000534818

E9PNF2
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E9PNF2 [Target identity:100%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

Show » « Hide

   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001708 [cell fate specification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002088 [lens development in camera-type eye]
GO:0005515 [protein binding]
GO:0007224 [smoothened signaling pathway]
GO:0007520 [myoblast fusion]
GO:0009952 [anterior/posterior pattern specification]
GO:0010172 [embryonic body morphogenesis]
GO:0014816 [satellite cell differentiation]
GO:0021987 [cerebral cortex development]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:2000179 [positive regulation of neural precursor cell proliferation]

111

11.7

Yes

CDON-010

ENSP00000436940
ENST00000527967

E9PPQ7
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E9PPQ7 [Target identity:100%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes
E9PNF2 [Target identity:77%; Query identity:100%]
Cell adhesion molecule-related/down-regulated by oncogenes

Show » « Hide

GO:0001708 [cell fate specification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002088 [lens development in camera-type eye]
GO:0005515 [protein binding]
GO:0007224 [smoothened signaling pathway]
GO:0007520 [myoblast fusion]
GO:0009952 [anterior/posterior pattern specification]
GO:0010172 [embryonic body morphogenesis]
GO:0014816 [satellite cell differentiation]
GO:0021987 [cerebral cortex development]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:2000179 [positive regulation of neural precursor cell proliferation]

143

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.