CLDN18

GENE INFORMATION

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Gene name

CLDN18 (HGNC Symbol)

Synonyms

SFTPJ

Description

Claudin 18 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

Chromosome

3

Cytoband

q22.3

Chromosome location (bp)

137717577 - 137752494

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000066405 (version 75.37)

Entrez gene

51208

UniProt

P56856 (UniProt - Evidence at protein level)

neXtProt

NX_P56856

Antibodypedia

CLDN18 antibodies
 

PROTEIN VIEW

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CLDN18-001
 
CLDN18-002
 
CLDN18-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN18-001 ENSP00000340939
ENST00000343735
P56856
Show all »
Show » Show » 261 27.7 No 3
CLDN18-002 ENSP00000183605
ENST00000183605
P56856
Show all »
Show » Show » 261 27.9 Yes 3
CLDN18-003 ENSP00000419732
ENST00000479660
F8WEY4
Show all »
Show » Show » 146 15.7 Yes 2