GUCY2C

TISSUE ATLAS

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Gene description

Guanylate cyclase 2C (heat stable enterotoxin receptor)

RNA tissue category

Group enriched (colon, duodenum, rectum, small intestine).

Protein summary

Detected at High or Medium expression level in 33 of 78 analyzed normal tissue cell types.

Protein expression

Most normal tissues showed weak to moderate cytoplasmic and occasional membranous staining. Respiratory epithelium of bronchus, neuronal cells in the CNS and stomach exhibited strong cytoplasmic positivity. Superficial layers of squamous epithelia displayed strong cytoplasmic nuclear positivity. Liver, decidual cells, spleen and most glial cells were negative.

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins

Predicted localization

Membrane

Protein evidence

Evidence at protein level

Protein reliability

Uncertain based on 1 antibody.
Liver
Colon
Kidney
Testis
Lymph node
Cerebral cortex
Oral mucosa
RNA Protein

Expression (FPKM)

Organ system

Localization (score)

100
50
0

h
m
l
n

Liver and pancreas
Liver
Gallbladder
Pancreas
Digestive tract (GI-tract)
N/A Oral mucosa
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Appendix
Colon
Rectum
Urinary tract (Kidney and bladder)
Kidney
Urinary bladder
Male reproductive system (Male tissues)
Testis
N/A Epididymis
Prostate
N/A Seminal vesicle
Breast and female reproductive system
N/A Breast
N/A Vagina
N/A Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Skin and soft tissues
Skin
Adipose tissue
Skeletal muscle
Smooth muscle
N/A Soft tissue
Blood and immune system (Hematopoietic)
Bone marrow
Lymph node
Tonsil
Spleen
Central nervous system (Brain)
Cerebral cortex
N/A Hippocampus
N/A Lateral ventricle
N/A Cerebellum
Endocrine glands
Thyroid gland
N/A Parathyroid gland
Adrenal gland
Respiratory system (Lung)
N/A Nasopharynx
N/A Bronchus
Lung
Cardiovascular system
Heart muscle

Antibodies in assay

HPA037655