Expression of CAMK2A in cancer - Staining overview

The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.

The cancers can be ordered histologically or alphabetically.

For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.

At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the literature conformity for the staining pattern revealed by that specific antibody.

Antibody HPA051783

Antibody HPA051785

Antibody HPA053973

Antibody CAB004330

Tissue

Antibody staining

Summary

Cancer tissues displayed weak to moderate cytoplasmic positivity. Several cases of melanomas, skin, renal and liver cancers were negative.

Several cases of liver and endometrial cancers showed moderate to strong cytoplasmic staining while lung cancers displayed moderate positivity. Several renal and pancreatic cancers exhibited weak to moderate cytoplasmic and membranous staining. Remaining cancer tissues were weakly stained or negative.

Moderate to strong cytoplasmic positivity was observed in a few gliomas. A few cases of thyroid, urothelial, testicular, colorectal, prostate and endometrial cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.

Breast, ovarian, urothelial, renal, gastric, pancreatic, liver cancer, malignant lymphomas showed moderate to strong cytoplasmic granular positivity. Malignant gliomas, melanomas, skin, colorectal and prostate cancer were weakly stained or negative.

Literature conformity

Consistent with extensive gene/protein characterization data

Partly consistent with extensive gene/protein characterization data

Consistent with extensive gene/protein characterization data

Partly consistent with extensive gene/protein characterization data

Level of antibody staining/expression

High
Medium
Low
Not detected

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.