TRIB2

GENE INFORMATION

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Gene name

TRIB2 (HGNC Symbol)

Synonyms

GS3955, TRB2

Description

Tribbles pseudokinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

2

Cytoband

p24.3

Chromosome location (bp)

12857015 - 12882860

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000071575 (version 75.37)

Entrez gene

28951

UniProt

Q92519 (UniProt - Evidence at transcript level)

neXtProt

NX_Q92519

Antibodypedia

TRIB2 antibodies
 

PROTEIN VIEW

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TRIB2-001
 
TRIB2-002
 
TRIB2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIB2-001 ENSP00000155926
ENST00000155926
Q92519
Show all »
Show » Show » 343 38.8 No 1
TRIB2-002 ENSP00000370874
ENST00000381465
F8WA18
Show all »
Show » Show » 207 23.6 No 1
TRIB2-004 ENSP00000384260
ENST00000405331
B5MCX4
Show all »
Show » Show » 252 28.5 No 2