IKBKG - Gene info - The Human Protein Atlas

IKBKG

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	IKBKG (HGNC Symbol)
Synonyms	FIP-3, FIP3, Fip3p, IKK-gamma, IP1, IP2, NEMO, ZC2HC9
Description	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (HGNC Symbol)
Entrez gene summary	This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153769414 - 153796782
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073009 (version 75.37)
Entrez gene	8517
UniProt	Q9Y6K9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6K9
Antibodypedia	IKBKG antibodies

PROTEIN VIEW

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IKBKG-002		IKBKG-003		IKBKG-004		IKBKG-005		IKBKG-006		IKBKG-007		IKBKG-008		IKBKG-009		IKBKG-011		IKBKG-012		IKBKG-013		IKBKG-014		IKBKG-016		IKBKG-017

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
IKBKG-002	ENSP00000358622 ENST00000369609	Q9Y6K9 Show all » « Hide Q9Y6K9 [Direct mapping] NF-kappa-B essential modulator D3DWY0 [Target identity:58%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b C9JN51 [Target identity:51%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:42%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:40%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:28%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006974 [response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019904 [protein domain specific binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	487	55.8	No	0
IKBKG-003	ENSP00000358620 ENST00000369607	Q9Y6K9 Show all » « Hide Q9Y6K9 [Direct mapping] NF-kappa-B essential modulator D3DWY0 [Target identity:68%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b C9JN51 [Target identity:59%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:49%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:46%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:32%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006974 [response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019904 [protein domain specific binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	419	48.2	No	0
IKBKG-004	ENSP00000358619 ENST00000369606	Q9Y6K9 Show all » « Hide Q9Y6K9 [Direct mapping] NF-kappa-B essential modulator D3DWY0 [Target identity:68%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b C9JN51 [Target identity:59%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:49%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:46%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:32%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006974 [response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019904 [protein domain specific binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	419	48.2	No	0
IKBKG-005	ENSP00000358614 ENST00000369601	Q9Y6K9 Show all » « Hide Q9Y6K9 [Direct mapping] NF-kappa-B essential modulator D3DWY0 [Target identity:68%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b C9JN51 [Target identity:59%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:49%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:46%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:32%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006974 [response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019904 [protein domain specific binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	419	48.2	No	0
IKBKG-006	ENSP00000358615 ENST00000369602	Q9Y6K9 Show all » « Hide Q9Y6K9 [Direct mapping] NF-kappa-B essential modulator C9JCG6 [Target identity:43%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006974 [response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019904 [protein domain specific binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	320	37	No	0
IKBKG-007	ENSP00000394934 ENST00000440286	C9JN51 Show all » « Hide C9JN51 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:82%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:77%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:54%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	251	28.8	No	0
IKBKG-008	ENSP00000390368 ENST00000422680	C9JH59 Show all » « Hide C9JH59 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:66%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	206	23.7	No	0
IKBKG-009	ENSP00000398579 ENST00000413620	C9J2V2 Show all » « Hide C9J2V2 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	195	22.3	No	0
IKBKG-011	ENSP00000263518 ENST00000263518	F8W9A9 Show all » « Hide F8W9A9 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator D3DWY2 [Target identity:63%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_a C9JCG6 [Target identity:37%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	368	42.4	No	0
IKBKG-012	ENSP00000395205 ENST00000445622	C9JCG6 Show all » « Hide C9JCG6 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	138	16.1	No	0
IKBKG-013	ENSP00000401308 ENST00000424839	C9JZ85 Show all » « Hide C9JZ85 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		190	21.7	No	0
IKBKG-014	ENSP00000420565 ENST00000470142	E7EU78 Show all » « Hide E7EU78 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator C9JH59 [Target identity:50%; Query identity:100%] NF-kappa-B essential modulator C9J2V2 [Target identity:47%; Query identity:100%] NF-kappa-B essential modulator C9JZ85 [Target identity:46%; Query identity:100%] NF-kappa-B essential modulator C9JCG6 [Target identity:33%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007250 [activation of NF-kappaB-inducing kinase activity] GO:0046982 [protein heterodimerization activity]	412	47.4	No	0
IKBKG-016	ENSP00000377180 ENST00000393549	A8MV29 Show all » « Hide A8MV29 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator C9JZ85 [Target identity:46%; Query identity:100%] NF-kappa-B essential modulator	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	411	47.3	No	0
IKBKG-017	ENSP00000400769 ENST00000455588	C9J1R1 Show all » « Hide C9J1R1 [Target identity:100%; Query identity:100%] NF-kappa-B essential modulator D3DWY0 [Target identity:68%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm]	418	48.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.