FSCN1

GENE INFORMATION

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Gene name

FSCN1 (HGNC Symbol)

Synonyms

FLJ38511, p55, SNL

Description

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

5632439 - 5646286

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075618 (version 75.37)

Entrez gene

6624

UniProt

Q16658 (UniProt - Evidence at protein level)

neXtProt

NX_Q16658

Antibodypedia

FSCN1 antibodies
 

PROTEIN VIEW

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FSCN1-001
 
FSCN1-003
 
FSCN1-004
 
FSCN1-005
 
FSCN1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FSCN1-001 ENSP00000371798
ENST00000382361
Q16658
Show all »
Show » Show » 493 54.5 No 0
FSCN1-003 ENSP00000404506
ENST00000444748
C9JFC0
Show all »
Show » Show » 132 14.8 No 0
FSCN1-004 ENSP00000409967
ENST00000447103
C9JPH9
Show all »
Show » Show » 120 13.5 No 0
FSCN1-005 ENSP00000383982
ENST00000405801
H7BYX5
Show all »
Show » Show » 138 15.5 No 0
FSCN1-201 ENSP00000339729
ENST00000340250
J3KNT0
Show all »
Show » Show » 472 52.3 No 0