SPAG6

GENE INFORMATION

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Gene name

SPAG6 (HGNC Symbol)

Synonyms

pf16, Repro-SA-1

Description

Sperm associated antigen 6 (HGNC Symbol)

Entrez gene summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

10

Cytoband

p12.2

Chromosome location (bp)

22634399 - 22743153

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077327 (version 75.37)

Entrez gene

9576

UniProt

O75602 (UniProt - Evidence at transcript level)

neXtProt

NX_O75602

Antibodypedia

SPAG6 antibodies
 

PROTEIN VIEW

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SPAG6-004
 
SPAG6-005
 
SPAG6-006
 
SPAG6-007
 
SPAG6-201
 
SPAG6-202
 
SPAG6-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPAG6-004 ENSP00000365811
ENST00000376624
O75602
Show all »
Show » Show » 509 55.5 No 0
SPAG6-005 ENSP00000323599
ENST00000313311
O75602
Show all »
Show » Show » 458 49.7 No 0
SPAG6-006 ENSP00000411111
ENST00000456231
Show » Show » 191 21.1 No 0
SPAG6-007 ENSP00000406594
ENST00000435326
Show » Show » 246 26.7 No 0
SPAG6-201 ENSP00000365786
ENST00000376601
O75602
Show all »
Show » Show » 270 30.1 No 0
SPAG6-202 ENSP00000365788
ENST00000376603
O75602
Show all »
Show » Show » 585 63.5 No 0
SPAG6-203 ENSP00000441325
ENST00000538630
O75602
Show all »
Show » Show » 484 52.5 No 0