SMARCA2 - Gene info - The Human Protein Atlas

SMARCA2

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	SMARCA2 (HGNC Symbol)
Synonyms	BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Chromosome	9
Cytoband	p24.3
Chromosome location (bp)	2015342 - 2193624
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080503 (version 75.37)
Entrez gene	6595
UniProt	P51531 (UniProt - Evidence at protein level)
neXtProt	NX_P51531
Antibodypedia	SMARCA2 antibodies

PROTEIN VIEW

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SMARCA2-001		SMARCA2-003		SMARCA2-004		SMARCA2-005		SMARCA2-006		SMARCA2-008		SMARCA2-009		SMARCA2-010		SMARCA2-011		SMARCA2-012		SMARCA2-013		SMARCA2-014		SMARCA2-015		SMARCA2-201		SMARCA2-202		SMARCA2-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SMARCA2-001	ENSP00000305411 ENST00000302401	B1ALF6 Show all » « Hide B1ALF6 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2 B4DNT1 [Target identity:99%; Query identity:100%] cDNA FLJ61143, highly similar to Probable global transcription activator SNF2L2 B1ALG1 [Target identity:84%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:63%; Query identity:100%] Probable global transcription activator SNF2L2 F6XE55 [Target identity:55%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:42%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	278	32	Yes	0
SMARCA2-003	ENSP00000371638 ENST00000382203	P51531 Show all » « Hide P51531 [Direct mapping] Probable global transcription activator SNF2L2 F6VDE0 [Target identity:35%; Query identity:100%] Probable global transcription activator SNF2L2 Q56A76 [Target identity:18%; Query identity:100%] SMARCA2 protein B1ALG2 [Target identity:15%; Query identity:100%] Probable global transcription activator SNF2L2 F6XDY1 [Target identity:10%; Query identity:100%] Probable global transcription activator SNF2L2 F6QYQ1 [Target identity:9%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:7%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:4%; Query identity:100%] Probable global transcription activator SNF2L2 Q6LC24 [Target identity:2%; Query identity:100%] Transcriptional activator hSNF2a	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0008285 [negative regulation of cell proliferation] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044212 [transcription regulatory region DNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1590	181.3	No	0
SMARCA2-004	ENSP00000371629 ENST00000382194	P51531 Show all » « Hide P51531 [Direct mapping] Probable global transcription activator SNF2L2 F6VDE0 [Target identity:35%; Query identity:100%] Probable global transcription activator SNF2L2 Q56A76 [Target identity:18%; Query identity:100%] SMARCA2 protein B1ALG1 [Target identity:15%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:11%; Query identity:100%] Probable global transcription activator SNF2L2 F6QYQ1 [Target identity:9%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:7%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:4%; Query identity:100%] Probable global transcription activator SNF2L2 Q6LC24 [Target identity:2%; Query identity:100%] Transcriptional activator hSNF2a	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0008285 [negative regulation of cell proliferation] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044212 [transcription regulatory region DNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1572	179.3	No	0
SMARCA2-005	ENSP00000409398 ENST00000439732	F6QYQ1 Show all » « Hide F6QYQ1 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:42%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	155	15.5	No	0
SMARCA2-006	ENSP00000415218 ENST00000457226	F6RS74 Show all » « Hide F6RS74 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	66	6.3	No	0
SMARCA2-008	ENSP00000392081 ENST00000450198	F6VDE0 Show all » « Hide F6VDE0 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2 Q56A76 [Target identity:53%; Query identity:100%] SMARCA2 protein F6QYQ1 [Target identity:27%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:11%; Query identity:100%] Probable global transcription activator SNF2L2 Q6LC24 [Target identity:6%; Query identity:100%] Transcriptional activator hSNF2a	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0045111 [intermediate filament cytoskeleton] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	559	61.9	No	0
SMARCA2-009	ENSP00000371620 ENST00000382185	B1ALG1 Show all » « Hide B1ALG1 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:75%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:50%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	236	27.5	No	0
SMARCA2-010	ENSP00000371621 ENST00000382186	B1ALG2 Show all » « Hide B1ALG2 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2 F6XDY1 [Target identity:67%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:46%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	254	29.5	No	0
SMARCA2-011	ENSP00000401096 ENST00000452193	F6XDY1 Show all » « Hide F6XDY1 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	171	20	No	0
SMARCA2-012	ENSP00000387486 ENST00000417599	F6XG14 Show all » « Hide F6XG14 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2 F6UH26 [Target identity:65%; Query identity:100%] Probable global transcription activator SNF2L2 F6XE55 [Target identity:56%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	271	31.3	Yes	0
SMARCA2-013	ENSP00000371618 ENST00000382183	B1ALG1 Show all » « Hide B1ALG1 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:75%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:50%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	236	27.5	No	0
SMARCA2-014	ENSP00000413057 ENST00000423555	F6XE55 Show all » « Hide F6XE55 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	153	17.7	Yes	0
SMARCA2-015	ENSP00000412242 ENST00000416751	F6UH26 Show all » « Hide F6UH26 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	177	20.9	No	0
SMARCA2-201	ENSP00000324770 ENST00000324954	B1ALG1 Show all » « Hide B1ALG1 [Target identity:100%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:75%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:50%; Query identity:100%] Probable global transcription activator SNF2L2	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0008285 [negative regulation of cell proliferation] GO:0035887 [aortic smooth muscle cell differentiation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	236	27.5	No	0
SMARCA2-202	ENSP00000265773 ENST00000349721	P51531 Show all » « Hide P51531 [Direct mapping] Probable global transcription activator SNF2L2 F6VDE0 [Target identity:35%; Query identity:100%] Probable global transcription activator SNF2L2 Q56A76 [Target identity:18%; Query identity:100%] SMARCA2 protein B1ALG2 [Target identity:15%; Query identity:100%] Probable global transcription activator SNF2L2 F6XDY1 [Target identity:10%; Query identity:100%] Probable global transcription activator SNF2L2 F6QYQ1 [Target identity:9%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:7%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:4%; Query identity:100%] Probable global transcription activator SNF2L2 Q6LC24 [Target identity:2%; Query identity:100%] Transcriptional activator hSNF2a	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0008285 [negative regulation of cell proliferation] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044212 [transcription regulatory region DNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1590	181.3	No	0
SMARCA2-203	ENSP00000349788 ENST00000357248	P51531 Show all » « Hide P51531 [Direct mapping] Probable global transcription activator SNF2L2 F6VDE0 [Target identity:35%; Query identity:100%] Probable global transcription activator SNF2L2 Q56A76 [Target identity:18%; Query identity:100%] SMARCA2 protein B1ALG1 [Target identity:15%; Query identity:100%] Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 F6UH26 [Target identity:11%; Query identity:100%] Probable global transcription activator SNF2L2 F6QYQ1 [Target identity:9%; Query identity:100%] Probable global transcription activator SNF2L2 B1ALG5 [Target identity:7%; Query identity:100%] Probable global transcription activator SNF2L2 F6RS74 [Target identity:4%; Query identity:100%] Probable global transcription activator SNF2L2 Q6LC24 [Target identity:2%; Query identity:100%] Transcriptional activator hSNF2a	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0008285 [negative regulation of cell proliferation] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044212 [transcription regulatory region DNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1572	179.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.