HSP90AA1 - Gene info - The Human Protein Atlas

Gene name

HSP90AA1 (HGNC Symbol)

Synonyms

FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Description

Heat shock protein 90kDa alpha (cytosolic), class A member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

Cytoband

q32.31

Chromosome location (bp)

102547075 - 102606036

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080824 (version 75.37)

Entrez gene

3320

UniProt

P07900 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSP90AA1-001

ENSP00000335153
ENST00000334701

P07900
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P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
K9JA46 [Target identity:85%; Query identity:100%]
Epididymis luminal secretory protein 52
Q8TBA7 [Target identity:74%; Query identity:100%]
HSP90AA1 protein
Q96HX7 [Target identity:49%; Query identity:100%]
HSP90AA1 protein
Q86SX1 [Target identity:30%; Query identity:100%]
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens (human)

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   COSMIC Somatic Mutations
   COSMIC Translocations
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0001764 [neuron migration]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003009 [skeletal muscle contraction]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006200 [ATP catabolic process]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0017098 [sulfonylurea receptor binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031012 [extracellular matrix]
GO:0031526 [brush border membrane]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0043627 [response to estrogen stimulus]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0046209 [nitric oxide metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0071682 [endocytic vesicle lumen]

854

98.2

HSP90AA1-002

ENSP00000216281
ENST00000216281

P07900
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P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
K9JA46 [Target identity:100%; Query identity:100%]
Epididymis luminal secretory protein 52
Q8TBA7 [Target identity:87%; Query identity:100%]
HSP90AA1 protein
Q96HX7 [Target identity:57%; Query identity:100%]
HSP90AA1 protein

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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0001764 [neuron migration]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003009 [skeletal muscle contraction]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006200 [ATP catabolic process]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0017098 [sulfonylurea receptor binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031012 [extracellular matrix]
GO:0031526 [brush border membrane]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0043627 [response to estrogen stimulus]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0046209 [nitric oxide metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0071682 [endocytic vesicle lumen]

732

84.7

HSP90AA1-003

ENSP00000451400
ENST00000554401

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005524 [ATP binding]

5.9

HSP90AA1-005

ENSP00000450712
ENST00000553585

G3V2J8
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G3V2J8 [Target identity:100%; Query identity:100%]
Heat shock protein HSP 90-alpha

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]

174

20.2

HSP90AA1-008

ENSP00000452241
ENST00000557234

G3V592
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G3V592 [Target identity:100%; Query identity:100%]
Heat shock protein HSP 90-alpha

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

9.2

HSP90AA1-201

ENSP00000396189
ENST00000441629

Q86U12
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Q86U12 [Target identity:100%; Query identity:100%]
Full-length cDNA clone CS0CAP007YF18 of Thymus of Homo sapiens (human); Heat shock protein HSP 90-alpha

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   COSMIC Somatic Mutations
   COSMIC Translocations
Cancer-related genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]

413

49.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.