APLP2

GENE INFORMATION

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Gene name

APLP2 (HGNC Symbol)

Synonyms

APPH, APPL2

Description

Amyloid beta (A4) precursor-like protein 2 (HGNC Symbol)

Entrez gene summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

11

Cytoband

q24.3

Chromosome location (bp)

129939732 - 130014699

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084234 (version 75.37)

Entrez gene

334

UniProt

Q06481 (UniProt - Evidence at protein level)

neXtProt

NX_Q06481

Antibodypedia

APLP2 antibodies
 

PROTEIN VIEW

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 « 
 
APLP2-001
 
APLP2-002
 
APLP2-003
 
APLP2-005
 
APLP2-008
 
APLP2-009
 
APLP2-010
 
APLP2-011
 
APLP2-018
 
APLP2-027
 
APLP2-201
 
APLP2-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APLP2-001 ENSP00000345444
ENST00000338167
Q06481
Show all »
Show » Show » 751 85.5 Yes 1
APLP2-002 ENSP00000263575
ENST00000345598
Q06481
Show all »
Show » Show » 522 59.2 Yes 1
APLP2-003 ENSP00000435914
ENST00000528499
Q06481
Show all »
Show » Show » 695 79.2 Yes 1
APLP2-005 ENSP00000263574
ENST00000263574
Q06481
Show all »
Show » Show » 763 87 Yes 1
APLP2-008 ENSP00000278756
ENST00000278756
Q06481
Show all »
Show » Show » 761 87.2 No 1
APLP2-009 ENSP00000434592
ENST00000533616
E9PPD0
Show all »
Show » Show » 39 3.9 Yes 0
APLP2-010 ENSP00000433582
ENST00000530132
Q9UED0
Show all »
Show » Show » 35 3.3 Yes 0
APLP2-011 ENSP00000434059
ENST00000533195
E9PSC7
Show all »
Show » Show » 159 17.3 Yes 0
APLP2-018 ENSP00000435470
ENST00000534582
E9PK76
Show all »
Show » Show » 116 12.3 Yes 0
APLP2-027 ENSP00000434379
ENST00000533713
E9PQS3
Show all »
Show » Show » 158 17.8 Yes 0
APLP2-201 ENSP00000443728
ENST00000539648
F5H845
Show all »
Show » Show » 551 63.5 No 1
APLP2-202 ENSP00000444122
ENST00000543137
F5GZY0
Show all »
Show » Show » 658 75.9 No 1