ORC1

GENE INFORMATION

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Gene name

ORC1 (HGNC Symbol)

Synonyms

HSORC1, ORC1L, PARC1

Description

Origin recognition complex, subunit 1 (HGNC Symbol)

Entrez gene summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

1

Cytoband

p32.3

Chromosome location (bp)

52838501 - 52870131

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000085840 (version 75.37)

Entrez gene

4998

UniProt

Q13415 (UniProt - Evidence at protein level)

neXtProt

NX_Q13415

Antibodypedia

ORC1 antibodies
 

PROTEIN VIEW

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ORC1-001
 
ORC1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ORC1-001 ENSP00000360623
ENST00000371568
Q13415
Show all »
Show » Show » 861 97.3 No 0
ORC1-002 ENSP00000360621
ENST00000371566
Q13415
Show all »
Show » Show » 861 97.3 No 0