PTPN4

GENE INFORMATION

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Gene name

PTPN4 (HGNC Symbol)

Synonyms

PTPMEG

Description

Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

120517207 - 120741394

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088179 (version 75.37)

Entrez gene

5775

UniProt

P29074 (UniProt - Evidence at protein level)

neXtProt

NX_P29074

Antibodypedia

PTPN4 antibodies
 

PROTEIN VIEW

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PTPN4-001
 
PTPN4-002
 
PTPN4-005
 
PTPN4-008
 
PTPN4-010
 
PTPN4-011
 
PTPN4-012
 
PTPN4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN4-001 ENSP00000263708
ENST00000263708
P29074
Show all »
Show » Show » 926 105.9 No 0
PTPN4-002 ENSP00000395603
ENST00000430976
Show » Show » 135 15.6 No 0
PTPN4-005 ENSP00000411364
ENST00000433888
J3QT89
Show all »
Show » Show » 121 14.2 No 0
PTPN4-008 ENSP00000394706
ENST00000441089
Show » Show » 219 25.1 No 0
PTPN4-010 ENSP00000387457
ENST00000431283
J3QT41
Show all »
Show » Show » 197 21.7 No 0
PTPN4-011 ENSP00000405763
ENST00000420482
J3KQP5
Show all »
Show » Show » 75 8.7 No 0
PTPN4-012 ENSP00000438445
ENST00000488279
F5H020
Show all »
Show » Show » 161 18.6 No 0
PTPN4-201 ENSP00000445841
ENST00000544261
F5H1A0
Show all »
Show » Show » 559 63 No 0