DAZL

GENE INFORMATION

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Gene name

DAZL (HGNC Symbol)

Synonyms

DAZH, DAZL1, DAZLA, MGC26406, SPGYLA

Description

Deleted in azoospermia-like (HGNC Symbol)

Entrez gene summary

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

3

Cytoband

p24.3

Chromosome location (bp)

16628299 - 16711813

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092345 (version 75.37)

Entrez gene

1618

UniProt

Q92904 (UniProt - Evidence at protein level)

neXtProt

NX_Q92904

Antibodypedia

DAZL antibodies
 

PROTEIN VIEW

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DAZL-001
 
DAZL-002
 
DAZL-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAZL-001 ENSP00000382373
ENST00000399444
Q92904
Show all »
Show » Show » 295 33.2 No 0
DAZL-002 ENSP00000250863
ENST00000250863
Q92904
Show all »
Show » Show » 315 35.2 No 0
DAZL-004 ENSP00000398109
ENST00000454457
E7EV40
Show all »
Show » Show » 204 22.5 No 0