HSP90AB1 - Gene info - The Human Protein Atlas

Gene name

HSP90AB1 (HGNC Symbol)

Synonyms

HSPC2, HSPCB

Description

Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Chromosome

Cytoband

p21.1

Chromosome location (bp)

44214824 - 44221620

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096384 (version 75.37)

Entrez gene

3326

UniProt

P08238 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSP90AB1-003

ENSP00000360709
ENST00000371646

P08238
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P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A8K3W9 [Target identity:50%; Query identity:100%]
cDNA FLJ77842

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   COSMIC Somatic Mutations
   COSMIC Translocations
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001890 [placenta development]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0016234 [inclusion body]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0019901 [protein kinase binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031526 [brush border membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0071353 [cellular response to interleukin-4]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]

724

83.3

HSP90AB1-004

ENSP00000325875
ENST00000353801

P08238
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P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A8K3W9 [Target identity:50%; Query identity:100%]
cDNA FLJ77842

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724

83.3

HSP90AB1-005

ENSP00000360609
ENST00000371554

P08238
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P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A8K3W9 [Target identity:50%; Query identity:100%]
cDNA FLJ77842

Show » « Hide

GO:0001890 [placenta development]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0016234 [inclusion body]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0019901 [protein kinase binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031526 [brush border membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0071353 [cellular response to interleukin-4]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]

724

83.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.