MMP11

GENE INFORMATION

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Gene name

MMP11 (HGNC Symbol)

Synonyms

STMY3

Description

Matrix metallopeptidase 11 (stromelysin 3) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.23

Chromosome location (bp)

24110413 - 24126503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099953 (version 75.37)

Entrez gene

4320

UniProt

P24347 (UniProt - Evidence at protein level)

neXtProt

NX_P24347

Antibodypedia

MMP11 antibodies
 

PROTEIN VIEW

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MMP11-001
 
MMP11-002
 
MMP11-004
 
MMP11-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP11-001 ENSP00000215743
ENST00000215743
P24347
Show all »
Show » Show » 488 54.6 Yes 0
MMP11-002 ENSP00000408070
ENST00000437086
E9PED7
Show all »
Show » Show » 354 38.8 Yes 0
MMP11-004 ENSP00000412107
ENST00000434318
Show » 170 18.6 No 0
MMP11-008 ENSP00000409860
ENST00000428253
F8WDI7
Show all »
Show » Show » 113 12.3 Yes 0