TOP3B

GENE INFORMATION

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Gene name

TOP3B

Synonyms

Description

Topoisomerase (DNA) III beta (HGNC Symbol)

Entrez gene summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Chromosome

22

Cytoband

q11.22

Chromosome location (bp)

22311397 - 22337213

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100038 (version 75.37)

Entrez gene

8940

UniProt

O95985 (UniProt - Evidence at transcript level)

neXtProt

NX_O95985

Antibodypedia

TOP3B antibodies
 

PROTEIN VIEW

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TOP3B-001
 
TOP3B-002
 
TOP3B-003
 
TOP3B-004
 
TOP3B-005
 
TOP3B-006
 
TOP3B-007
 
TOP3B-008
 
TOP3B-009
 
TOP3B-010
 
TOP3B-011
 
TOP3B-012
 
TOP3B-013
 
TOP3B-014
 
TOP3B-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOP3B-001 ENSP00000349705
ENST00000357179
O95985
Show all »
Show » Show » 862 96.7 No 0
TOP3B-002 ENSP00000392480
ENST00000444502
F2Z2A5
Show all »
Show » Show » 129 14.4 No 0
TOP3B-003 ENSP00000381773
ENST00000398793
O95985
Show all »
Show » Show » 862 96.7 No 0
TOP3B-004 ENSP00000397221
ENST00000457179
F2Z2A5
Show all »
Show » Show » 129 14.4 No 0
TOP3B-005 ENSP00000416451
ENST00000436282
H7C4B0
Show all »
Show » Show » 168 18.7 No 0
TOP3B-006 ENSP00000408282
ENST00000457270
B3KU89
Show all »
Show » Show » 525 59.3 No 0
TOP3B-007 ENSP00000414538
ENST00000430142
C9JKE2
Show all »
Show » Show » 121 13.4 No 0
TOP3B-008 ENSP00000390824
ENST00000434517
Show » 21 2.3 No 0
TOP3B-009 ENSP00000391857
ENST00000456075
C9J9X4
Show all »
Show » Show » 61 6.4 No 0
TOP3B-010 ENSP00000387554
ENST00000437103
C9JTQ7
Show all »
Show » Show » 42 4.4 No 0
TOP3B-011 ENSP00000404600
ENST00000449704
C9JEQ1
Show all »
Show » Show » 60 6.3 No 0
TOP3B-012 ENSP00000390977
ENST00000424393
C9JEI7
Show all »
Show » Show » 246 27.4 No 0
TOP3B-013 ENSP00000402622
ENST00000437929
C9JT00
Show all »
Show » Show » 122 13.5 No 0
TOP3B-014 ENSP00000390209
ENST00000442653
C9JHR0
Show all »
Show » Show » 47 4.9 No 0
TOP3B-201 ENSP00000393118
ENST00000413067
E7EWY2
Show all »
Show » Show » 282 31.2 No 0