PLA2G3

GENE INFORMATION

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Gene name

PLA2G3 (HGNC Symbol)

Synonyms

GIII-SPLA2

Description

Phospholipase A2, group III (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

31530795 - 31536593

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100078 (version 75.37)

Entrez gene

50487

UniProt

Q9NZ20 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZ20

Antibodypedia

PLA2G3 antibodies
 

PROTEIN VIEW

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PLA2G3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLA2G3-001 ENSP00000215885
ENST00000215885
Q9NZ20
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