DOK5

GENE INFORMATION

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Gene name

DOK5 (HGNC Symbol)

Synonyms

C20orf180, dJ805C22.1

Description

Docking protein 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

20

Cytoband

q13.2

Chromosome location (bp)

53092136 - 53267710

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101134 (version 75.37)

Entrez gene

55816

UniProt

Q9P104 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P104

Antibodypedia

DOK5 antibodies
 

PROTEIN VIEW

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DOK5-001
 
DOK5-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOK5-001 ENSP00000262593
ENST00000262593
Q9P104
Show all »
Show » 306 35.5 No 0
DOK5-002 ENSP00000379270
ENST00000395939
Q9P104
Show all »
Show » 198 22.8 No 0