PGK1

GENE INFORMATION

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Gene name

PGK1

Synonyms

Description

Phosphoglycerate kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

Chromosome

X

Cytoband

q21.1

Chromosome location (bp)

77320685 - 77384793

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102144 (version 75.37)

Entrez gene

5230

UniProt

P00558 (UniProt - Evidence at protein level)

neXtProt

NX_P00558

Antibodypedia

PGK1 antibodies
 

PROTEIN VIEW

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PGK1-001
 
PGK1-201
 
PGK1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGK1-001 ENSP00000362413
ENST00000373316
P00558
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Show » Show » 417 44.6 No 0
PGK1-201 ENSP00000405452
ENST00000442431
E7ERH5
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Show » Show » 281 30 No 0
PGK1-202 ENSP00000444708
ENST00000537456
B7Z7A9
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Show » Show » 389 41.4 No 0