MSLN

GENE INFORMATION

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Gene name

MSLN (HGNC Symbol)

Synonyms

CAK1, MPF

Description

Mesothelin (HGNC Symbol)

Entrez gene summary

This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

810762 - 818865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102854 (version 75.37)

Entrez gene

10232

UniProt

Q13421 (UniProt - Evidence at protein level)

neXtProt

NX_Q13421

Antibodypedia

MSLN antibodies
 

PROTEIN VIEW

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MSLN-001
 
MSLN-002
 
MSLN-003
 
MSLN-004
 
MSLN-005
 
MSLN-006
 
MSLN-007
 
MSLN-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSLN-001 ENSP00000372313
ENST00000382862
Q13421
Show all »
Show » Show » 630 69 Yes 1
MSLN-002 ENSP00000456702
ENST00000566549
Q13421
Show all »
Show » Show » 622 68.1 Yes 1
MSLN-003 ENSP00000456008
ENST00000563941
Q13421
Show all »
Show » Show » 622 68.1 Yes 1
MSLN-004 ENSP00000442965
ENST00000545450
Q13421
Show all »
Show » Show » 622 68.1 Yes 1
MSLN-005 ENSP00000454295
ENST00000566269
Show » 334 37.6 No 0
MSLN-006 ENSP00000457847
ENST00000561896
H3BUX1
Show all »
Show » 398 43.8 No 0
MSLN-007 ENSP00000458003
ENST00000569566
H3BV92
Show all »
Show » Show » 171 18.2 Yes 0
MSLN-008 ENSP00000456132
ENST00000563651
H3BR90
Show all »
Show » Show » 333 36.8 Yes 0