SLC6A2

GENE INFORMATION

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Gene name

SLC6A2 (HGNC Symbol)

Synonyms

NAT1, NET, NET1, SLC6A5

Description

Solute carrier family 6 (neurotransmitter transporter), member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Chromosome

16

Cytoband

q12.2

Chromosome location (bp)

55689516 - 55740104

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103546 (version 75.37)

Entrez gene

6530

UniProt

P23975 (UniProt - Evidence at protein level)

neXtProt

NX_P23975

Antibodypedia

SLC6A2 antibodies
 

PROTEIN VIEW

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SLC6A2-001
 
SLC6A2-003
 
SLC6A2-004
 
SLC6A2-005
 
SLC6A2-006
 
SLC6A2-007
 
SLC6A2-008
 
SLC6A2-009
 
SLC6A2-010
 
SLC6A2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC6A2-001 ENSP00000369237
ENST00000379906
P23975
Show all »
Show » Show » 617 69.3 No >9
SLC6A2-003 ENSP00000394956
ENST00000414754
H3BM11
Show all »
Show » Show » 561 62.9 No >9
SLC6A2-004 ENSP00000457473
ENST00000568943
P23975
Show all »
Show » Show » 617 69.3 No >9
SLC6A2-005 ENSP00000457375
ENST00000567238
B4DX48
Show all »
Show » Show » 512 57.4 No >9
SLC6A2-006 ENSP00000456210
ENST00000566163
H3BRE9
Show all »
Show » Show » 572 64.3 No >9
SLC6A2-007 ENSP00000454439
ENST00000561820
H3BML6
Show all »
Show » Show » 604 67.7 No >9
SLC6A2-008 ENSP00000454603
ENST00000568655
H3BMY5
Show all »
Show » Show » 200 22.4 No 3
SLC6A2-009 ENSP00000456377
ENST00000568529
H3BRS0
Show all »
Show » Show » 295 33.2 No 5
SLC6A2-010 ENSP00000460214
ENST00000574918
Show » 58 6.3 No 0
SLC6A2-201 ENSP00000219833
ENST00000219833
P23975
Show all »
Show » Show » 628 70.5 No >9