IKBKB - Gene info - The Human Protein Atlas

IKBKB

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	IKBKB (HGNC Symbol)
Synonyms	IKK-beta, IKK2, IKKB, NFKBIKB
Description	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42128820 - 42189973
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104365 (version 75.37)
Entrez gene	3551
UniProt	O14920 (UniProt - Evidence at protein level)
neXtProt	NX_O14920
Antibodypedia	IKBKB antibodies

PROTEIN VIEW

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IKBKB-001		IKBKB-002		IKBKB-003		IKBKB-004		IKBKB-005		IKBKB-006		IKBKB-008		IKBKB-011		IKBKB-012		IKBKB-013		IKBKB-017		IKBKB-018		IKBKB-019		IKBKB-020		IKBKB-021		IKBKB-022		IKBKB-201		IKBKB-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
IKBKB-001	ENSP00000339151 ENST00000342222	J3KNS5 Show all » « Hide J3KNS5 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	164	18.4	No	0
IKBKB-002	ENSP00000430684 ENST00000520810	O14920 Show all » « Hide O14920 [Direct mapping] Inhibitor of nuclear factor kappa-B kinase subunit beta E5RGW5 [Target identity:49%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Kinases Plasma proteins RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007252 [I-kappaB phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0008385 [IkappaB kinase complex] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0009615 [response to virus] GO:0009898 [internal side of plasma membrane] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019901 [protein kinase binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042501 [serine phosphorylation of STAT protein] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356 [cellular response to tumor necrosis factor] GO:2001259 [positive regulation of cation channel activity]	756	86.6	No	0
IKBKB-003	ENSP00000428799 ENST00000517890	E5RGA0 Show all » « Hide E5RGA0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.2	No	0
IKBKB-004	ENSP00000430483 ENST00000519735	O14920 Show all » « Hide O14920 [Direct mapping] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Kinases Plasma proteins RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007252 [I-kappaB phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0008385 [IkappaB kinase complex] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0009615 [response to virus] GO:0009898 [internal side of plasma membrane] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019901 [protein kinase binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042501 [serine phosphorylation of STAT protein] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356 [cellular response to tumor necrosis factor] GO:2001259 [positive regulation of cation channel activity]	256	29.2	No	0
IKBKB-005	ENSP00000429239 ENST00000523105	E5RGA0 Show all » « Hide E5RGA0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.2	No	0
IKBKB-006	ENSP00000430868 ENST00000520835	O14920 Show all » « Hide O14920 [Direct mapping] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Kinases Plasma proteins RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007252 [I-kappaB phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0008385 [IkappaB kinase complex] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0009615 [response to virus] GO:0009898 [internal side of plasma membrane] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019901 [protein kinase binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042501 [serine phosphorylation of STAT protein] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356 [cellular response to tumor necrosis factor] GO:2001259 [positive regulation of cation channel activity]	754	85.9	No	0
IKBKB-008	ENSP00000430557 ENST00000518679	E5RJH2 Show all » « Hide E5RJH2 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		43	4.8	No	0
IKBKB-011	ENSP00000428186 ENST00000521661	G3V105 Show all » « Hide G3V105 [Target identity:100%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_b; Inhibitor of nuclear factor kappa-B kinase subunit beta E5RGW5 [Target identity:66%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:2001259 [positive regulation of cation channel activity]	562	63.7	No	0
IKBKB-012	ENSP00000428922 ENST00000520655	G3V105 Show all » « Hide G3V105 [Target identity:100%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_b; Inhibitor of nuclear factor kappa-B kinase subunit beta E5RGW5 [Target identity:66%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:2001259 [positive regulation of cation channel activity]	562	63.7	No	0
IKBKB-013	ENSP00000430114 ENST00000523517	E5RGW5 Show all » « Hide E5RGW5 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:2001259 [positive regulation of cation channel activity]	375	42.7	No	0
IKBKB-017	ENSP00000429699 ENST00000520320	E5RGA0 Show all » « Hide E5RGA0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.2	No	0
IKBKB-018	ENSP00000429357 ENST00000517812	E5RGA0 Show all » « Hide E5RGA0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.2	No	0
IKBKB-019	ENSP00000427978 ENST00000518983	E5RFT3 Show all » « Hide E5RFT3 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		76	8.3	No	0
IKBKB-020	ENSP00000429924 ENST00000517388	E5RGA0 Show all » « Hide E5RGA0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.2	No	0
IKBKB-021	ENSP00000429319 ENST00000519733	E5RIW0 Show all » « Hide E5RIW0 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		51	5.8	No	0
IKBKB-022	ENSP00000428892 ENST00000522147	E5RFG5 Show all » « Hide E5RFG5 [Target identity:100%; Query identity:100%] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		109	12.1	No	0
IKBKB-201	ENSP00000369030 ENST00000379708	B3KRB7 Show all » « Hide B3KRB7 [Target identity:100%; Query identity:100%] Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_a; Inhibitor of nuclear factor kappa-B kinase subunit beta; cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta	Show » « Hide RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008384 [IkappaB kinase activity]	533	60.8	No	0
IKBKB-202	ENSP00000404920 ENST00000416505	O14920 Show all » « Hide O14920 [Direct mapping] Inhibitor of nuclear factor kappa-B kinase subunit beta	Show » « Hide Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Kinases Plasma proteins RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001782 [B cell homeostasis] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007252 [I-kappaB phosphorylation] GO:0008384 [IkappaB kinase activity] GO:0008385 [IkappaB kinase complex] GO:0009615 [response to virus] GO:0009898 [internal side of plasma membrane] GO:0010765 [positive regulation of sodium ion transport] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0032481 [positive regulation of type I interferon production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042501 [serine phosphorylation of STAT protein] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356 [cellular response to tumor necrosis factor] GO:2001259 [positive regulation of cation channel activity]	697	79.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.