GSR

GENE INFORMATION

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Gene name

GSR

Synonyms

Description

Glutathione reductase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

Chromosome

8

Cytoband

p12

Chromosome location (bp)

30535583 - 30585443

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104687 (version 75.37)

Entrez gene

2936

UniProt

P00390 (UniProt - Evidence at protein level)

neXtProt

NX_P00390

Antibodypedia

GSR antibodies
 

PROTEIN VIEW

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GSR-001
 
GSR-002
 
GSR-003
 
GSR-004
 
GSR-201
 
GSR-202
 
GSR-203
 
GSR-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GSR-001 ENSP00000221130
ENST00000221130
P00390
Show all »
Show » Show » 522 56.3 No 0
GSR-002 ENSP00000430825
ENST00000521479
E5RI06
Show all »
Show » Show » 145 15.8 No 0
GSR-003 ENSP00000429247
ENST00000520888
Show » Show » 301 32.1 No 0
GSR-004 ENSP00000431044
ENST00000523295
H0YC68
Show all »
Show » Show » 131 14.2 No 0
GSR-201 ENSP00000390065
ENST00000414019
P00390
Show all »
Show » Show » 479 51.7 No 0
GSR-202 ENSP00000438845
ENST00000537535
P00390
Show all »
Show » Show » 440 47.3 No 0
GSR-203 ENSP00000444559
ENST00000541648
P00390
Show all »
Show » Show » 469 50.5 No 0
GSR-204 ENSP00000445516
ENST00000546342
P00390
Show all »
Show » Show » 493 53 No 0