NUDT1

GENE INFORMATION

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Gene name

NUDT1 (HGNC Symbol)

Synonyms

MTH1

Description

Nudix (nucleoside diphosphate linked moiety X)-type motif 1 (HGNC Symbol)

Entrez gene summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

2281857 - 2290781

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106268 (version 75.37)

Entrez gene

4521

UniProt

P36639 (UniProt - Evidence at protein level)

neXtProt

NX_P36639

Antibodypedia

NUDT1 antibodies
 

PROTEIN VIEW

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NUDT1-001
 
NUDT1-002
 
NUDT1-003
 
NUDT1-004
 
NUDT1-005
 
NUDT1-006
 
NUDT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NUDT1-001 ENSP00000349148
ENST00000356714
P36639
Show all »
Show » Show » 156 18 No 0
NUDT1-002 ENSP00000380239
ENST00000397046
P36639
Show all »
Show » Show » 156 18 No 0
NUDT1-003 ENSP00000380241
ENST00000397048
P36639
Show all »
Show » Show » 179 20.3 No 0
NUDT1-004 ENSP00000339503
ENST00000343985
P36639
Show all »
Show » Show » 179 20.3 No 0
NUDT1-005 ENSP00000343439
ENST00000339737
P36639
Show all »
Show » Show » 156 18 No 0
NUDT1-006 ENSP00000405334
ENST00000454650
C9J361
Show all »
Show » Show » 37 4 No 0
NUDT1-201 ENSP00000380242
ENST00000397049
P36639
Show all »
Show » Show » 179 20.3 No 0