Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
|
EZH2-001 |
ENSP00000419856
ENST00000483967
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2 Q75MP9 [Target identity:90%; Query identity:100%]Putative uncharacterized protein EZH2
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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737 |
84.4 |
No |
0 |
EZH2-003 |
ENSP00000417377
ENST00000492143
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G3XAL2 Show all »
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G3XAL2 [Target identity:100%; Query identity:100%]Enhancer of zeste homolog 2 (Drosophila), isoform CRA_b; Histone-lysine N-methyltransferase EZH2 Q59H64 [Target identity:100%; Query identity:88%]Enhancer of zeste homolog 2 variant Q6R125 [Target identity:85%; Query identity:100%]EZH2 protein B7Z8L6 [Target identity:67%; Query identity:100%]Histone-lysine N-methyltransferase EZH2; cDNA FLJ52824, highly similar to Enhancer of zeste homolog 2
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COSMIC Missense Mutations COSMIC Somatic Mutations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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334 |
38.9 |
No |
0 |
EZH2-004 |
ENSP00000320147
ENST00000320356
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2 Q75MQ0 [Target identity:89%; Query identity:100%]Putative uncharacterized protein EZH2 Q6R125 [Target identity:38%; Query identity:100%]EZH2 protein
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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751 |
86 |
No |
0 |
EZH2-005 |
ENSP00000417704
ENST00000483012
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E9PDH6 Show all »
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E9PDH6 [Target identity:100%; Query identity:100%]Histone-lysine N-methyltransferase EZH2
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins COSMIC Missense Mutations COSMIC Somatic Mutations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0018024 [histone-lysine N-methyltransferase activity]
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144 |
16.8 |
No |
0 |
EZH2-006 |
ENSP00000417062
ENST00000478654
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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695 |
79.6 |
No |
0 |
EZH2-007 |
ENSP00000419050
ENST00000476773
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2
|
Show »
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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695 |
79.6 |
No |
0 |
EZH2-008 |
ENSP00000419711
ENST00000460911
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Q15910 Show all »
« Hide
Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2 Q75MP9 [Target identity:89%; Query identity:100%]Putative uncharacterized protein EZH2 Q6R125 [Target identity:38%; Query identity:100%]EZH2 protein
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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746 |
85.4 |
No |
0 |
EZH2-010 |
ENSP00000223193
ENST00000350995
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2 S4S3R8 [Target identity:100%; Query identity:100%]EZH2b
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Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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707 |
81 |
No |
0 |
EZH2-201 |
ENSP00000439305
ENST00000536783
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B7Z8L6 Show all »
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B7Z8L6 [Target identity:100%; Query identity:100%]Histone-lysine N-methyltransferase EZH2; cDNA FLJ52824, highly similar to Enhancer of zeste homolog 2
|
Show »
« Hide
COSMIC Missense Mutations COSMIC Somatic Mutations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
225 |
26.2 |
No |
0 |
EZH2-202 |
ENSP00000443219
ENST00000541220
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Q15910 Show all »
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Q15910 [Direct mapping]Histone-lysine N-methyltransferase EZH2
|
Show »
« Hide
Transferases COSMIC Missense Mutations COSMIC Somatic Mutations Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0014013 [regulation of gliogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021695 [cerebellar cortex development] GO:0032320 [positive regulation of Ras GTPase activity] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0035098 [ESC/E(Z) complex] GO:0042054 [histone methyltransferase activity] GO:0042127 [regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045605 [negative regulation of epidermal cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0051154 [negative regulation of striated muscle cell differentiation] GO:0070314 [G1 to G0 transition] GO:0070734 [histone H3-K27 methylation] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
|
695 |
79.6 |
No |
0 |