POU6F2

GENE INFORMATION

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Gene name

POU6F2 (HGNC Symbol)

Synonyms

RPF-1

Description

POU class 6 homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Chromosome

7

Cytoband

p14.1

Chromosome location (bp)

39017598 - 39532694

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106536 (version 75.37)

Entrez gene

11281

UniProt

P78424 (UniProt - Evidence at protein level)

neXtProt

NX_P78424

Antibodypedia

POU6F2 antibodies
 

PROTEIN VIEW

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POU6F2-001
 
POU6F2-002
 
POU6F2-003
 
POU6F2-004
 
POU6F2-005
 
POU6F2-006
 
POU6F2-007
 
POU6F2-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POU6F2-001 ENSP00000430514
ENST00000518318
P78424
Show all »
Show » Show » 655 69.2 No 0
POU6F2-002 ENSP00000384004
ENST00000403058
P78424
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Show » Show » 691 73.3 No 0
POU6F2-003 ENSP00000409684
ENST00000451021
C9JSC0
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Show » 145 15 No 0
POU6F2-004 ENSP00000475747
ENST00000464276
U3KQC3
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62 6.6 No 0
POU6F2-005 ENSP00000404868
ENST00000416452
H7C2B2
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Show » 142 14.6 Yes 0
POU6F2-006 ENSP00000452911
ENST00000524147
H0YKR5
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Show » 412 42.7 No 0
POU6F2-007 ENSP00000453020
ENST00000520104
H0YL15
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Show » 403 41.6 No 0
POU6F2-012 ENSP00000452633
ENST00000559001
H0YK27
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Show » Show » 636 67.9 No 0