RLN1

GENE INFORMATION

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Gene name

RLN1 (HGNC Symbol)

Synonyms

H1

Description

Relaxin 1 (HGNC Symbol)

Entrez gene summary

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

Chromosome

9

Cytoband

p24.1

Chromosome location (bp)

5334969 - 5339873

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000107018 (version 75.37)

Entrez gene

6013

UniProt

P04808 (UniProt - Evidence at transcript level)

neXtProt

NX_P04808

Antibodypedia

RLN1 antibodies
 

PROTEIN VIEW

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RLN1-001
 
RLN1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RLN1-001 ENSP00000223862
ENST00000223862
P04808
Show all »
Show » Show » 185 21.1 Yes 0
RLN1-201 ENSP00000223858
ENST00000223858
P04808
Show all »
Show » Show » 117 13 Yes 0