TLX1

GENE INFORMATION

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Gene name

TLX1 (HGNC Symbol)

Synonyms

HOX11, TCL3

Description

T-cell leukemia homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Chromosome

10

Cytoband

q24.31

Chromosome location (bp)

102889257 - 102897545

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107807 (version 75.37)

Entrez gene

3195

UniProt

P31314 (UniProt - Evidence at protein level)

neXtProt

NX_P31314

Antibodypedia

TLX1 antibodies
 

PROTEIN VIEW

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TLX1-001
 
TLX1-002
 
TLX1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLX1-001 ENSP00000359215
ENST00000370196
P31314
Show all »
Show » Show » 330 34.4 No 0
TLX1-002 ENSP00000434358
ENST00000463716
G3V1B7
Show all »
Show » 218 21.4 No 0
TLX1-003 ENSP00000434914
ENST00000467928
P31314
Show all »
Show » Show » 257 26.2 No 0