P2RX1

GENE INFORMATION

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Gene name

P2RX1 (HGNC Symbol)

Synonyms

P2X1

Description

Purinergic receptor P2X, ligand-gated ion channel, 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]

Chromosome

17

Cytoband

p13.2

Chromosome location (bp)

3799886 - 3819794

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108405 (version 75.37)

Entrez gene

5023

UniProt

P51575 (UniProt - Evidence at protein level)

neXtProt

NX_P51575

Antibodypedia

P2RX1 antibodies
 

PROTEIN VIEW

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P2RX1-002
 
P2RX1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RX1-002 ENSP00000225538
ENST00000225538
P51575
Show all »
Show » Show » 399 45 No 2
P2RX1-003 ENSP00000460449
ENST00000571637
I3L3H3
Show all »
Show » Show » 57 6.7 No 1