GABRA4

GENE INFORMATION

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Gene name

GABRA4

Synonyms

Description

Gamma-aminobutyric acid (GABA) A receptor, alpha 4 (HGNC Symbol)

Entrez gene summary

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

Chromosome

4

Cytoband

p12

Chromosome location (bp)

46920917 - 46996424

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109158 (version 75.37)

Entrez gene

2557

UniProt

P48169 (UniProt - Evidence at transcript level)

neXtProt

NX_P48169

Antibodypedia

GABRA4 antibodies
 

PROTEIN VIEW

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GABRA4-001
 
GABRA4-003
 
GABRA4-004
 
GABRA4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GABRA4-001 ENSP00000264318
ENST00000264318
P48169
Show all »
Show » Show » 554 61.6 Yes 4
GABRA4-003 ENSP00000422152
ENST00000511523
D6R924
Show all »
Show » 36 4.3 No 0
GABRA4-004 ENSP00000425445
ENST00000508560
D6R924
Show all »
Show » 36 4.3 No 0
GABRA4-005 ENSP00000424386
ENST00000502874
D6RB66
Show all »
Show » 36 3.9 Yes 0