GLRB

GENE INFORMATION

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Gene name

GLRB

Synonyms

Description

Glycine receptor, beta (HGNC Symbol)

Entrez gene summary

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

4

Cytoband

q32.1

Chromosome location (bp)

157997209 - 158093242

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109738 (version 75.37)

Entrez gene

2743

UniProt

P48167 (UniProt - Evidence at protein level)

neXtProt

NX_P48167

Antibodypedia

GLRB antibodies
 

PROTEIN VIEW

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GLRB-001
 
GLRB-002
 
GLRB-003
 
GLRB-004
 
GLRB-005
 
GLRB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLRB-001 ENSP00000264428
ENST00000264428
P48167
Show all »
Show » Show » 497 56.1 Yes 4
GLRB-002 ENSP00000427186
ENST00000509282
P48167
Show all »
Show » Show » 497 56.1 Yes 4
GLRB-003 ENSP00000422039
ENST00000506411
D6R9Y9
Show all »
Show » 46 5.4 Yes 0
GLRB-004 ENSP00000421044
ENST00000515642
D6R9Y9
Show all »
Show » 46 5.4 Yes 0
GLRB-005 ENSP00000425433
ENST00000512619
D6RD86
Show all »
Show » 56 6.4 Yes 0
GLRB-201 ENSP00000441873
ENST00000541722
P48167
Show all »
Show » Show » 303 34.9 Yes 1