SLC22A18

GENE INFORMATION

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Gene name

SLC22A18 (HGNC Symbol)

Synonyms

BWR1A, BWSCR1A, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5

Description

Solute carrier family 22, member 18 (HGNC Symbol)

Entrez gene summary

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

2920951 - 2946476

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110628 (version 75.37)

Entrez gene

5002

UniProt

Q96BI1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96BI1

Antibodypedia

SLC22A18 antibodies
 

PROTEIN VIEW

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SLC22A18-001
 
SLC22A18-002
 
SLC22A18-003
 
SLC22A18-005
 
SLC22A18-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC22A18-001 ENSP00000311139
ENST00000312221
Q96BI1
Show all »
Show » Show » 424 44.8 No >9
SLC22A18-002 ENSP00000307859
ENST00000347936
Q96BI1
Show all »
Show » Show » 424 44.8 No >9
SLC22A18-003 ENSP00000369948
ENST00000380574
Q96BI1
Show all »
Show » Show » 424 44.8 No >9
SLC22A18-005 ENSP00000392072
ENST00000449793
E9PRM7
Show all »
Show » Show » 326 35 No 8
SLC22A18-012 ENSP00000433019
ENST00000485423
E9PMN7
Show all »
Show » 134 14.2 No 3