NUP98

GENE INFORMATION

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Gene name

NUP98 (HGNC Symbol)

Synonyms

NUP96

Description

Nucleoporin 98kDa (HGNC Symbol)

Entrez gene summary

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

3692313 - 3819022

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110713 (version 75.37)

Entrez gene

4928

UniProt

P52948 (UniProt - Evidence at protein level)

neXtProt

NX_P52948

Antibodypedia

NUP98 antibodies
 

PROTEIN VIEW

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 « 
 
NUP98-001
 
NUP98-002
 
NUP98-003
 
NUP98-004
 
NUP98-012
 
NUP98-013
 
NUP98-014
 
NUP98-015
 
NUP98-017
 
NUP98-018
 
NUP98-019
 
NUP98-020
 
NUP98-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NUP98-001 ENSP00000316032
ENST00000324932
P52948
Show all »
Show » Show » 1800 195.8 No 0
NUP98-002 ENSP00000380199
ENST00000397004
P52948
Show all »
Show » Show » 920 96.1 No 0
NUP98-003 ENSP00000413146
ENST00000429801
Show » 753 85.7 No 0
NUP98-004 ENSP00000380202
ENST00000397007
P52948
Show all »
Show » Show » 937 97.8 No 0
NUP98-012 ENSP00000434698
ENST00000532475
E9PNN0
Show all »
Show » 124 11.9 No 0
NUP98-013 ENSP00000347404
ENST00000355260
P52948
Show all »
Show » Show » 1726 187.2 No 0
NUP98-014 ENSP00000433515
ENST00000524563
Show » 232 26.8 No 0
NUP98-015 ENSP00000433226
ENST00000529063
Show » 75 8.2 No 0
NUP98-017 ENSP00000432142
ENST00000529379
Show » 179 18.4 No 0
NUP98-018 ENSP00000380208
ENST00000397013
Show » 136 13.6 No 0
NUP98-019 ENSP00000436226
ENST00000527104
Q9HDC8
Show all »
Show » 235 24.1 No 0
NUP98-020 ENSP00000432275
ENST00000533346
Show » 93 10.5 No 0
NUP98-201 ENSP00000352091
ENST00000359171
J3KP29
Show all »
Show » Show » 1638 177.4 No 0